This lecture overviews an important topic of Digital Humanities, namely digital painting analysis that has many applications in painting conservation and in the history of arts. It covers the following topics in detail: Structure from Motion (SfM) in 3D monument and painting reconstruction, fragmented artefact re-assembly, IR reflectography and mosaicking, image registration, crack restoration, color restoration. Finally,  stylistic painting analysis and computational aesthetics will be overviewed.